Enrichment analysis of Gene Ontology biological process terms in tumors with upregulation of the CIN signature. Heat map of tumor samples as columns and Gene Ontology biological process terms as rows. Color codes are as described in Figure 2. The top part of the heat map shows the p53 mutation and estrogen receptor (ER) status in each sample. The samples with upregulation of the CIN signature significantly upregulate genes annotated with 'cell cycle', 'DNA replication' and downregulate genes related to 'cell adhesion', 'cell communication', and so on.