Tumors with upregulation of the CIN signature are addicted to DNA repair. (a) Heat-map of tumor samples as columns and genes or modules as rows. Color codes are as described in Figure 2. The top part of the heat map shows the p53 mutation and estrogen receptor (ER) status in each sample. The samples with up-regulation of the CIN signature significantly upregulate genes annotated with DNA damage/repair-related categories and gene signatures related to DNA damage signaling network around ATM-BRCA1 (from MSigDB). (b) Selected genes involved in DNA damage repair.