Figure 8
From: Sample-level enrichment analysis unravels shared stress phenotypes among multiple cancer types
Pathway interdependencies. Oncogenic signaling causes stress through many different, interrelated mechanisms. These mechanisms include: 1) up-regulation of the CIN-related genes; 2) activation of transcriptional program related to senescence-bypass; 3) upregulation of DNA damage response pathways; 4) upregulation of proteotoxic stress response mechanisms; 5) upregulation of mitotic stress response mechanisms; and 6) upregulation of metabolic pathways regulated by TORC1/HIF1 activation.