The ovarian gene regulatory network. The ovarian network inferred using SIRENE, showing target genes (rectangles) and transcription factors (circles). Two clusters of genes (shaded blue, in the centre of the figure) switch regulators between the two conditions, controlled by SP3 or NFκB1 in normal and by E2F1 in cancer. Bold nodes are known to have protein products that are targeted by anti-cancer drugs. Edge colors: green, normal; orange, cancer; blue, both. Edge line type: bold, literature and TFBS; solid, literature; dashed, TFBS; dotted, no evidence.