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Table 2 Metabolites found to be differentially abundant in 1H NMR and GC-MS in pair of patient groups

From: Serum metabolomic profile as a means to distinguish stage of colorectal cancer

Group comparison, analytical platform Increased in liver-limited metastases Decreased in liver-limited metastases
  Metabolite P Metabolite P
Liver-only disease versus locoregional disease, 1H NMR 2-Aminobutyrate 0.07 Isoleucine 0.13
  2-Hydroxyisovalerate 0.05 Mannose 0.10
  ß-Alanine 0.09 O-Phosphocholine 0.08
  Formate 0.005 Hypoxantine 0.10
  Histidine 0.16 Creatinine 0.11
  Glutamate 0.0007 2-Oxoglutarate 0.02
  Isobutyrate 0.002 Glutamine 0.0004
    Glycerol 0.05
Liver-only disease versus locoregional disease, GC-MS Azelaic acid 0.11 Ribose 0.03
  Pentacosane 0.30 Trehalose 0.22
  Tridecan-1-ol 0.19 Cysteamine 0.15
  Pyroglutamate 0.13 Heneicosane 0.13
  Idose 0.04 Glutamine 0.10
    Benzyl alcohol 0.19
    Myo-inositol 0.23
    Nonadecane 0.13
    Galactose 0.03
    Mannose 0.02
Extrahepatic metastases versus liver-only disease, 1H-NMR Isoleucine 0.03 Methionine 0.07
  2-Oxoglutarate 0.07 Fumarate 0.23
  Mannose 0.07 Tyrosine 0.24
  Glutamine 0.12 Serine 0.07
  Leucine 0.12 Formate 0.10
  2-Aminobutyrate 0.16 Alanine 0.17
    Glutamate 0.14
Extrahepatic metastases versus liver-only disease, GC-MS Tridecan-1-ol 0.003 Butanoic acid, 3-hydroxy 0.12
  Sulfuric acid 0.25 Glutamine 0.14
  Pentadecan-1-ol 0.07 Glucuronic acid 0.05
  Phenylalanine 0.10 Myo-inositol 0.23
  Tetradecanoic acid 0.03 Uric acid 0.30
  Octadecadienoic acid 0.03 Glucose 0.16
  1. Metabolites in these tables were selected based on the two-sample t-test statistics used for data filtering (P-value < 0.30) and the threshold of variable importance in the projection (VIP) > 0.8. Correlation with the model comparison is determined by scaled and centered coefficients.