From: Serum metabolomic profile as a means to distinguish stage of colorectal cancer
Group comparison, analytical platform | Increased in liver-limited metastases | Decreased in liver-limited metastases | ||
---|---|---|---|---|
 | Metabolite | P | Metabolite | P |
Liver-only disease versus locoregional disease, 1H NMR | 2-Aminobutyrate | 0.07 | Isoleucine | 0.13 |
 | 2-Hydroxyisovalerate | 0.05 | Mannose | 0.10 |
 | ß-Alanine | 0.09 | O-Phosphocholine | 0.08 |
 | Formate | 0.005 | Hypoxantine | 0.10 |
 | Histidine | 0.16 | Creatinine | 0.11 |
 | Glutamate | 0.0007 | 2-Oxoglutarate | 0.02 |
 | Isobutyrate | 0.002 | Glutamine | 0.0004 |
 |  |  | Glycerol | 0.05 |
Liver-only disease versus locoregional disease, GC-MS | Azelaic acid | 0.11 | Ribose | 0.03 |
 | Pentacosane | 0.30 | Trehalose | 0.22 |
 | Tridecan-1-ol | 0.19 | Cysteamine | 0.15 |
 | Pyroglutamate | 0.13 | Heneicosane | 0.13 |
 | Idose | 0.04 | Glutamine | 0.10 |
 |  |  | Benzyl alcohol | 0.19 |
 |  |  | Myo-inositol | 0.23 |
 |  |  | Nonadecane | 0.13 |
 |  |  | Galactose | 0.03 |
 |  |  | Mannose | 0.02 |
Extrahepatic metastases versus liver-only disease, 1H-NMR | Isoleucine | 0.03 | Methionine | 0.07 |
 | 2-Oxoglutarate | 0.07 | Fumarate | 0.23 |
 | Mannose | 0.07 | Tyrosine | 0.24 |
 | Glutamine | 0.12 | Serine | 0.07 |
 | Leucine | 0.12 | Formate | 0.10 |
 | 2-Aminobutyrate | 0.16 | Alanine | 0.17 |
 |  |  | Glutamate | 0.14 |
Extrahepatic metastases versus liver-only disease, GC-MS | Tridecan-1-ol | 0.003 | Butanoic acid, 3-hydroxy | 0.12 |
 | Sulfuric acid | 0.25 | Glutamine | 0.14 |
 | Pentadecan-1-ol | 0.07 | Glucuronic acid | 0.05 |
 | Phenylalanine | 0.10 | Myo-inositol | 0.23 |
 | Tetradecanoic acid | 0.03 | Uric acid | 0.30 |
 | Octadecadienoic acid | 0.03 | Glucose | 0.16 |