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Table 2 Metabolites found to be differentially abundant in 1H NMR and GC-MS in pair of patient groups

From: Serum metabolomic profile as a means to distinguish stage of colorectal cancer

Group comparison, analytical platform

Increased in liver-limited metastases

Decreased in liver-limited metastases

 

Metabolite

P

Metabolite

P

Liver-only disease versus locoregional disease, 1H NMR

2-Aminobutyrate

0.07

Isoleucine

0.13

 

2-Hydroxyisovalerate

0.05

Mannose

0.10

 

ß-Alanine

0.09

O-Phosphocholine

0.08

 

Formate

0.005

Hypoxantine

0.10

 

Histidine

0.16

Creatinine

0.11

 

Glutamate

0.0007

2-Oxoglutarate

0.02

 

Isobutyrate

0.002

Glutamine

0.0004

   

Glycerol

0.05

Liver-only disease versus locoregional disease, GC-MS

Azelaic acid

0.11

Ribose

0.03

 

Pentacosane

0.30

Trehalose

0.22

 

Tridecan-1-ol

0.19

Cysteamine

0.15

 

Pyroglutamate

0.13

Heneicosane

0.13

 

Idose

0.04

Glutamine

0.10

   

Benzyl alcohol

0.19

   

Myo-inositol

0.23

   

Nonadecane

0.13

   

Galactose

0.03

   

Mannose

0.02

Extrahepatic metastases versus liver-only disease, 1H-NMR

Isoleucine

0.03

Methionine

0.07

 

2-Oxoglutarate

0.07

Fumarate

0.23

 

Mannose

0.07

Tyrosine

0.24

 

Glutamine

0.12

Serine

0.07

 

Leucine

0.12

Formate

0.10

 

2-Aminobutyrate

0.16

Alanine

0.17

   

Glutamate

0.14

Extrahepatic metastases versus liver-only disease, GC-MS

Tridecan-1-ol

0.003

Butanoic acid, 3-hydroxy

0.12

 

Sulfuric acid

0.25

Glutamine

0.14

 

Pentadecan-1-ol

0.07

Glucuronic acid

0.05

 

Phenylalanine

0.10

Myo-inositol

0.23

 

Tetradecanoic acid

0.03

Uric acid

0.30

 

Octadecadienoic acid

0.03

Glucose

0.16

  1. Metabolites in these tables were selected based on the two-sample t-test statistics used for data filtering (P-value < 0.30) and the threshold of variable importance in the projection (VIP) > 0.8. Correlation with the model comparison is determined by scaled and centered coefficients.