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Table 1 Clinical, genetic and biochemical comparisons of XP, CS and UVSS

From: UVSSA and USP7: new players regulating transcription-coupled nucleotide excision repair in human cells

 

XP

CS

UVSS

Sun-sensitivity

Yes

Yes

Yes

Skin cancers

Yes

No

No

Progressive neurological degeneration

Yes/noa

Yes

No

Developmental abnormalities

No

Yes

No

Ageing

Yes/noa

Yes

No

UV-DNA repair deficiency

Yes

Yes

Yes

ROS-DNA repair deficiency

Yes/noa

Yes

No

Complementation groups

7

2

3

Involved genes

XPA to XPGb

CSA and CSB

CSA, CSB and UVSSA

  1. aSome XP patients exhibit XP and CS (mutated on XPA, XPB, XPD and XPG). bSeven genes are involved in XP. CS, Cockayne syndrome; ROS, reactive oxygen species; UV, ultraviolet; UVSS, UV-sensitivity syndrome; XP, xeroderma pigmentosum.