|
XP
|
CS
|
UVSS
|
---|
Sun-sensitivity
|
Yes
|
Yes
|
Yes
|
Skin cancers
|
Yes
|
No
|
No
|
Progressive neurological degeneration
|
Yes/noa
|
Yes
|
No
|
Developmental abnormalities
|
No
|
Yes
|
No
|
Ageing
|
Yes/noa
|
Yes
|
No
|
UV-DNA repair deficiency
|
Yes
|
Yes
|
Yes
|
ROS-DNA repair deficiency
|
Yes/noa
|
Yes
|
No
|
Complementation groups
|
7
|
2
|
3
|
Involved genes
|
XPA to XPGb
|
CSA and CSB
|
CSA, CSB and UVSSA
|
- aSome XP patients exhibit XP and CS (mutated on XPA, XPB, XPD and XPG). bSeven genes are involved in XP. CS, Cockayne syndrome; ROS, reactive oxygen species; UV, ultraviolet; UVSS, UV-sensitivity syndrome; XP, xeroderma pigmentosum.