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Figure 1 | Genome Medicine

Figure 1

From: Consensus: a framework for evaluation of uncertain gene variants in laboratory test reporting

Figure 1

Cross-validation for individual predictor performance. (a) Calculated area under the curve (AUC) of RET predictor cross-validation results for individual predictor performance, including PSAAP (0.971), MutPred (0.845), PMut (0.698), PolyPhen-2 (0.555) and SIFT (0.630). (b) AUC results for the gene-specific predictor PSAAP (0.971), the combined predictor Consensus (0.998) and ConDel (0.587) with overcall of 'pathogenic' results for actual benign variants.

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