From: Consensus: a framework for evaluation of uncertain gene variants in laboratory test reporting
Predictor | Prin1 | Â | Prin2 | Â | Prin3 | Â |
---|---|---|---|---|---|---|
PSAAP | 0.56 | Â | 0.25 | Â | 0.25 | Â |
MutPred | 0.62 | Â | 0.14 | Â | 0.22 | Â |
PMUT | 0.46 | Â | 0.36 | Â | -0.06 | Â |
PolyPhen | -0.27 | Â | 0.40 | Â | 0.77 | Â |
1-SIFT | 0.06 | Â | 0.79 | Â | -0.54 | Â |
Varianta | PSAPPb | MutPredc | PMUTd | PolyPhene | SIFTf | Â |
Pathogenic | Â | Â | Â | Â | Â | Â |
C609Y | 0.85 | 0.90 | 0.98 | 0.97 | 0.00 | Â |
Vector1 = | 0.85 × 0.56 | +0.90 × 0.62 | +0.98 × 0.46 | +0.97 × -0.27 | +(1-0.00) × 0.06 | = 1.283 |
Vector2 = | 0.85 × 0.25 | +0.90 × 0.14 | +0.98 × 0.36 | +0.97 × 0.40 | +(1-0.00) × 0.79 | = 1.869 |
Vector3 = | 0.85 × 0.25 | +0.90 × 0.22 | +0.98 × -0.06 | +0.97 × 0.77 | +(1-0.00) × -0.54 | = 0.559 |
 |  |  |  |  | Weighted sum (× 100) | = 371.1 |
Benign | Â | Â | Â | Â | Â | Â |
V376A | 0.07 | 0.13 | 0.19 | 0.04 | 0.60 | Â |
Vector1 = | 0.07 × 0.56 | +0.13 × 0.62 | +0.19 × 0.46 | +0.04 × -0.27 | +(1-0.60) × 0.06 | = 0.220 |
Vector2 = | 0.07 × 0.25 | +0.13 × 0.14 | +0.19 × 0.36 | +0.04 × 0.40 | +(1-0.60) × 0.79 | = 0.436 |
Vector3 = | 0.07 × 0.25 | +0.13 × 0.22 | +0.19 × -0.06 | +0.04 × 0.77 | +(1-0.60) × -0.54 | = - 0.150 |
 |  |  |  |  | Weighted sum (× 100) | = 50.6 |