TY - JOUR AU - Alfirevic, Ana AU - Gonzalez-Galarza, Faviel AU - Bell, Catherine AU - Martinsson, Klara AU - Platt, Vivien AU - Bretland, Giovanna AU - Evely, Jane AU - Lichtenfels, Maike AU - Cederbrant, Karin AU - French, Neil AU - Naisbitt, Dean AU - Park, B. Kevin AU - Jones, Andrew R. AU - Pirmohamed, Munir PY - 2012 DA - 2012/06/25 TI - In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers JO - Genome Medicine SP - 51 VL - 4 IS - 6 AB - Drug-induced liver injury (DILI) is one of the most common adverse reactions leading to product withdrawal post-marketing. Recently, genome-wide association studies have identified a number of human leukocyte antigen (HLA) alleles associated with DILI; however, the cellular and chemical mechanisms are not fully understood. SN - 1756-994X UR - https://doi.org/10.1186/gm350 DO - 10.1186/gm350 ID - Alfirevic2012 ER -