Haplotype combinations between HLA-B*57:01 and HLA-DRB1 alleles. All haplotype combinations (colored lines) of the HLA-B*57:01 allele with HLA-DRB1 alleles reported in the dbMHC database are shown (n = 8,569). Haplotype frequencies were estimated using the Expectation Maximization algorithm described in PyPop . Frequencies > 1% are shown in bold whereas frequencies < 1% are represented by dotted lines. Circles in red correspond to alleles that have been associated with DILI. As shown, high LD can be observed between the B*57:01 and DRB1*07:01 alleles, which have been associated with DILI. This picture was automatically generated using the GraphViz software  and is available as Scalable Vector Graphics (SVG) file.