Figure 2

Examples of reported interactions between genetic and non-genetic factors in determining antidepressant treatment response. Work looking at the relationship between potential response predictors indicates that antidepressant treatment response is determined by multiple interacting factors. For example, genetic variation in GRIK4 (glutamate receptor, ionotropic, kainate 4) has been reported to have both a main effect and interactive effects with FKBP5 (FK506 binding protein 5) and HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G-protein-coupled) in its influence on response outcomes [45]. Similarly, an association between the occurrence of stressful life events and response may be moderated by genetic variation in SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) [50, 51].