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Table 1 Symptoms and classification of depression

From: Genome-wide approaches to antidepressant treatment: working towards understanding and predicting response

Depressive symptoms DSM-IV classification of depressive episode ICD-10 classification of depressive episode
(1) Depressed mood for at least 2 weeks Five or more symptoms, including (1) or (2) Mild: four or more symptoms, including two of (1), (2) or (3)Moderate: six or more symptoms, including two of (1), (2) or (3)Severe: eight or more symptoms, including (1), (2) and (3)
(2) Loss of interest and enjoyment   
(3) Increased fatigability   
(4) Loss of confidence/self-esteema   
(5) Self-reproach/guilt   
(6) Suicidal thoughts or intent   
(7) Reduced concentration/indecisiveness   
(8) Agitation   
(9) Sleep disturbance   
(10) Altered appetite   
Course Single episode or recurrent Single episode or recurrent
Additional specifiers With/without psychotic featuresb With/without psychotic featuresb (severe depression only)
  With/without catatonic features With/without somatic symptoms
  With/without atypical features  
  With/without postpartum onset  
  1. aThis symptom is not outlined in DSM-IV; bpatients with psychotic features are generally excluded from the studies detailed in this review.
  2. DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4th edition [3]; ICD-10, International Classification of Diseases, 10th revision [4].