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Table 1 Symptoms and classification of depression

From: Genome-wide approaches to antidepressant treatment: working towards understanding and predicting response

Depressive symptoms

DSM-IV classification of depressive episode

ICD-10 classification of depressive episode

(1) Depressed mood for at least 2 weeks

Five or more symptoms, including (1) or (2)

Mild: four or more symptoms, including two of (1), (2) or (3)Moderate: six or more symptoms, including two of (1), (2) or (3)Severe: eight or more symptoms, including (1), (2) and (3)

(2) Loss of interest and enjoyment


(3) Increased fatigability


(4) Loss of confidence/self-esteema


(5) Self-reproach/guilt


(6) Suicidal thoughts or intent


(7) Reduced concentration/indecisiveness


(8) Agitation


(9) Sleep disturbance


(10) Altered appetite



Single episode or recurrent

Single episode or recurrent

Additional specifiers

With/without psychotic featuresb

With/without psychotic featuresb (severe depression only)


With/without catatonic features

With/without somatic symptoms


With/without atypical features


With/without postpartum onset

  1. aThis symptom is not outlined in DSM-IV; bpatients with psychotic features are generally excluded from the studies detailed in this review.
  2. DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4th edition [3]; ICD-10, International Classification of Diseases, 10th revision [4].