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Tricyclic antidepressants (TCAs)
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Nortriptyline, amitriptyline, imipramine, dothiepin
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Block norepinephrine and serotonin reuptake transporters; also antagonize serotoninergic, histaminergic, adrenergic and cholinergic receptors
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Common side effects include dry mouth and constipation; cardiovascular issues can occur; fatal in overdose
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Selective serotonin reuptake inhibitors (SSRIs)
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Fluoxetine, sertraline, paroxetine, citalopram, escitalopram
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Block serotonin reuptake transporters; more selective than TCAs
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Common side effects include nausea, sexual dysfunction; lower cardiotoxicity than TCAs (therefore safer in overdose)
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Serotonin-norepinephrine reuptake inhibitors (SNRIs)
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Venlafaxine, duloxetine
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Block norepinephrine and serotonin reuptake transporters; more selective than TCAs
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Common side effects similar to SSRIs; also associated with increased blood pressure
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