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Figure 3 | Genome Medicine

Figure 3

From: Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability

Figure 3

Simplified map and interactions of the phosphoinositide 3-kinase (PI3K) and RASpathways highlighting the genomic aberrations (-, loss of function mutation,*gain of function mutation) identified in a cancer of the ampulla of Vater andthe putative therapeutic site of vulnerability. ERK,extracellular-signal-regulated kinase; grb2, growth factor receptor bound protein2; mTOR, mammalian target of rapamycin; RTK, receptor tyrosine kinase; SHC, SHC(Src homology 2 domain containing) transforming protein 1; SOS, son ofsevenless.

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