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Table 4 Stroke odds ratio for E-alone and E+P, by genotype of SNPs in PCSK9 region

From: Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk

  

SNP genotype

  
 

Number of cases

AA

AG

GG

  
  

OR

95% CI

OR

95% CI

OR

95% CI

p-2df

p-1df

rs630431

         

   E-alone

         

All

351

1.704

(1.227, 2.366)

1.064

(0.772, 1.468)

0.871

(0.499, 1.519)

0.04796

0.0166

Ischemic

263

1.994

(1.362, 2.919)

1.321

(0.906, 1.925)

0.767

(0.393, 1.498)

0.03845

0.01104

Hemorrhagic

48

0.651

(0.252, 1.678)

0.682

(0.306, 1.517)

0.682

(0.114, 4.079)

0.9971

0.94614

   E+P

         

All

438

0.935

(0.719, 1.217)

1.616

(1.192, 2.191)

1.978

(1.021, 3.834)

0.00919

0.00291

Ischemic

319

0.916

(0.667, 1.257)

1.550

(1.094, 2.197)

2.434

(1.126, 5.260)

0.01578

0.00401

Hemorrhagic

76

0.724

(0.399, 1.314)

2.143

(0.932, 4.929)

0.953

(0.192, 4.719)

0.10243

0.14652

rs568052

         

   E-alone

         

All

351

1.716

(1.233, 2.389)

1.050

(0.762, 1.446)

0.909

(0.524, 1.575)

0.04909

0.01939

Ischemic

263

2.019

(1.373, 2.967)

1.294

(0.889, 1.882)

0.818

(0.424, 1.578)

0.04487

0.01272

Hemorrhagic

48

0.651

(0.252, 1.678)

0.682

(0.306, 1.517)

0.682

(0.114, 4.079)

0.9971

0.94614

   E+P

         

All

438

0.961

(0.738, 1.251)

1.555

(1.150, 2.103)

1.978

(1.021, 3.834)

0.02051

0.0061

Ischemic

319

0.953

(0.693, 1.309)

1.474

(1.043, 2.082)

2.434

(1.126, 5.260)

0.03335

0.00918

Hemorrhagic

76

0.724

(0.399, 1.314)

2.143

(0.932, 4.929)

0.953

(0.192, 4.719)

0.10243

0.14652

  1. OR, estimated intervention odds ratio. p-2df, P-value regressing randomization assignment on indicator for one or two minor alleles. p-1df, P-value regressing randomization assignment on number of minor alleles. CI, confidence interval.
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