Skip to main content

Table 4 Stroke odds ratio for E-alone and E+P, by genotype of SNPs in PCSK9 region

From: Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk

   SNP genotype   
  Number of cases AA AG GG   
   OR 95% CI OR 95% CI OR 95% CI p-2df p-1df
rs630431          
   E-alone          
All 351 1.704 (1.227, 2.366) 1.064 (0.772, 1.468) 0.871 (0.499, 1.519) 0.04796 0.0166
Ischemic 263 1.994 (1.362, 2.919) 1.321 (0.906, 1.925) 0.767 (0.393, 1.498) 0.03845 0.01104
Hemorrhagic 48 0.651 (0.252, 1.678) 0.682 (0.306, 1.517) 0.682 (0.114, 4.079) 0.9971 0.94614
   E+P          
All 438 0.935 (0.719, 1.217) 1.616 (1.192, 2.191) 1.978 (1.021, 3.834) 0.00919 0.00291
Ischemic 319 0.916 (0.667, 1.257) 1.550 (1.094, 2.197) 2.434 (1.126, 5.260) 0.01578 0.00401
Hemorrhagic 76 0.724 (0.399, 1.314) 2.143 (0.932, 4.929) 0.953 (0.192, 4.719) 0.10243 0.14652
rs568052          
   E-alone          
All 351 1.716 (1.233, 2.389) 1.050 (0.762, 1.446) 0.909 (0.524, 1.575) 0.04909 0.01939
Ischemic 263 2.019 (1.373, 2.967) 1.294 (0.889, 1.882) 0.818 (0.424, 1.578) 0.04487 0.01272
Hemorrhagic 48 0.651 (0.252, 1.678) 0.682 (0.306, 1.517) 0.682 (0.114, 4.079) 0.9971 0.94614
   E+P          
All 438 0.961 (0.738, 1.251) 1.555 (1.150, 2.103) 1.978 (1.021, 3.834) 0.02051 0.0061
Ischemic 319 0.953 (0.693, 1.309) 1.474 (1.043, 2.082) 2.434 (1.126, 5.260) 0.03335 0.00918
Hemorrhagic 76 0.724 (0.399, 1.314) 2.143 (0.932, 4.929) 0.953 (0.192, 4.719) 0.10243 0.14652
  1. OR, estimated intervention odds ratio. p-2df, P-value regressing randomization assignment on indicator for one or two minor alleles. p-1df, P-value regressing randomization assignment on number of minor alleles. CI, confidence interval.