Skip to main content

Table 2 New variants found in the newly sequenced Spanish population (AND) arranged by chromosome location

From: A map of human microRNA variation uncovers unexpectedly high levels of variability

Location

SNV

Pre-mir/mature

Region

Number of individuals

Population frequency (%)

Number of heterozygous

Number of homozygous

Validated

Chr1:236016354

C/G

hsa-mir-1537

5' mir (mix)

1

0.0868

1

0

Yes

Chr 3:10436198

G/A

hsa-mir-885/hsa-miR-885-3p

3' seed miR

1

0.0868

1

0

Yes

Chr 3:75679944

C/T

hsa-mir-1324

5' mir (mix)

2

0.1736

2

0

NCa

Chr 4:8007067

G/A

hsa-mir-95

5' mir (mix)

1

0.0868

1

0

Yes

Chr 9:97847780

C/T

hsa-mir-27b

Loop

1

0.0868

1

0

Yes

Chr 12:49048256

G/A

hsa-mir-1291

3' mir (mix)

1

0.0868

1

0

Yes

Chr 14:23887249

C/G

hsa-mir-208b

5' mir (mix)

1

0.0868

1

0

NDb

Chr 14:101347358

C/T

hsa-mir-431

5' mir

1

0.0868

1

0

Yes

Chr 14:101506800

G/C

hsa-mir-376b

5' mir (mix)

1

0.0868

1

0

Yes

Chr 14:101513665

A/T

hsa-mir-539

5' mir

1

0.0868

1

0

Yes

Chr 14:101531692

T/C

hsa-mir-409/hsa-miR-409-3p

3' rom miR

1

0.0868

1

0

Yes

  1. Location, the location (chromosome:position, according to the human genome build GRCh37, hg19); SNV, the change observed (reference allele/alternative allele); Pre-mir/mature, the identifier of the pre-mir and the mature miRNA affected by the SNV; Region, the region in which the SNV maps within the miRNA structure (Figure 3, bottom), with several cases where regions cannot be defined with precision due to a lack of a detailed annotation (3' mir (mix) = loop + seed miR 3' + rest of miR 3' + 3' pre-mir; 5' mir (mix) = loop + seed miR 5' + rest of miR 5' + 5' pre-mir; we also use the abbreviations 5' rom miR = rest of miR 5' and 3' rom miR = rest of miR 3'); Number of individuals, the number of individuals supporting the SNV; Population frequency (%), the alternative allele frequency in the studied population; Number of heterozygous, the number of times the SNV occurred heterozygously; Number of homozygous, the number of times that the alternative allele occurred homozygously. aNC, non-conclusive results after using two independent pairs of primers; a double band makes a precise determination of the SNV impossible. bND, not determined because no more DNA was available.