Skip to main content

Table 3 SNVs found in all the populations analysed affecting critical regions of miRNAs

From: A map of human microRNA variation uncovers unexpectedly high levels of variability

Location SNV Pre-mir/mature [dbSNP]/[1000g aaf] Region Number of samples Population frequency (%) Number of heterozygous Number of homozygous
1:17185500 C/T hsa-mir-3675/hsa-miR-3675-5p RS137982850/- 5' seed miR 1 0.0868 0 1
1:100746814 A/G hsa-mir-553/hsa-miR-553 -/0.00 5' seed miR 3 0.2604 3 0
1:176998565 T/C hsa-miR-488-5p -/0.00 5' seed miR 1 0.0868 1 0
3:164059159 G/A hsa-mir-720/hsa-miR-720 -/0.00 5' seed miR 1 0.0868 1 0
4:113569088 A/G hsa-miR-367-5p RS150161032/0.00 5' seed miR 1 0.0868 1 0
5:140027435 C/T hsa-mir-3655/hsa-miR-3655 RS146400503/0.01 5' seed miR 13 1.1285 13 0
7:73605546 C/T hsa-mir-590/hsa-miR-590-5p -/0.00 5' seed miR 4 0.3472 4 0
7:127721934 C/T hsa-miR-593-5p RS73721294/0.02 5' seed miR 42 3.6458 40 2
10:29891260 C/T hsa-mir-938/hsa-miR-938 RS12416605/0.15 5' seed miR 301 26.1285 261 40
10:53059349 A/G hsa-mir-605/hsa-miR-605 RS113212828/0.00 5' seed miR 8 0.6944 8 0
10:105807928 T/C hsa-mir-936/hsa-miR-936 RS79924817/0.01 5' seed miR 11 0.9549 11 0
13:53384209 C/G hsa-mir-759/hsa-miR-759 RS144233096/0.00 5' seed miR 4 0.3472 4 0
14:101520657 T/C hsa-miR-382-5p -/0.00 5' seed miR 1 0.0868 1 0
15:42491848 A/C hsa-mir-627/hsa-miR-627 RS2620381/0.08 5' seed miR 157 13.6285 145 12
19:46178206 T/G hsa-miR-642a-5p RS78902025/0.00 5' seed miR 1 0.0868 1 0
1:3477292 C/T hsa-mir-551a/hsa-miR-551a -/0.00 3' seed miR 10 0.8681 10 0
1:168344829 C/T hsa-mir-557/hsa-miR-557 RS78825966/0.06 3' seed miR 114 9.8958 98 16
2:176032384 T/C hsa-mir-933/hsa-miR-933 RS139770589/0.00 3' seed miR 8 0.6944 8 0
3:10436198 G/Aa hsa-mir-885/hsa-miR-885-3p New varianta 3' seed miR 1 0.0868 1 0
3:49311593 G/C hsa-mir-4271/hsa-miR-4271 -/0.00 3' seed miR 2 0.1736 2 0
3:160122434 G/A hsa-miR-15b-3p -/0.00 3' seed miR 1 0.0868 1 0
4:1988144 C/A hsa-mir-943/hsa-miR-943 -/0.00 3' seed miR 2 0.1736 2 0
4:83674520 G/A hsa-mir-575/hsa-miR-575 RS149186367/0.00 3' seed miR 10 0.8681 10 0
4:117220909 G/A hsa-mir-1973/hsa-miR-1973 -/0.00 3' seed miR 1 0.0868 1 0
5:54468124 A/T hsa-miR-449c-3p RS35770269/0.25 3' seed miR 460 39.9306 368 92
5:148810267 C/T hsa-miR-145-3p -/0.00 3' seed miR 1 0.0868 1 0
5:159912418 C/G hsa-miR-146a-3p RS2910164/0.62 3' seed miR 933 80.9896 458 475
5:168690635 C/T hsa-mir-585/hsa-miR-585 RS62376935/0.10 3' seed miR 199 17.2743 176 23
7:150935577 G/A hsa-mir-671/hsa-miR-671-3p -/0.00 3' seed miR 1 0.0868 1 0
8:10682898 A/G hsa-mir-1322/hsa-miR-1322 -/0.00 3' seed miR 5 0.434 5 0
10:29833959 C/T hsa-mir-604/hsa-miR-604 -/0.00 3' seed miR 3 0.2604 3 0
12:113132901 G/A hsa-mir-1302-1/hsa-miR-1302 RS74647838/0.03 3' seed miR 53 4.6007 50 3
14:101351088 A/C hsa-miR-136-3p RS147448304/0.00 3' seed miR 1 0.0868 1 0
16:820249 G/A hsa-mir-662/hsa-miR-662 RS9745376/0.05 3' seed miR 97 8.4201 87 10
16:2321809 G/A hsa-mir-940/hsa-miR-940 RS149527765/0.00 3' seed miR 1 0.0868 1 0
18:56118358 C/T hsa-miR-122-3p RS41292412/0.00 3' seed miR 10 0.8681 10 0
19:2234080 G/A hsa-mir-1227/hsa-miR-1227 RS139405773/0.00 3' seed miR 2 0.1736 2 0
19:10662866 G/A hsa-mir-1238/hsa-miR-1238 -/0.00 3' seed miR 1 0.0868 1 0
19:10928119 A/G hsa-mir-199a-1/hsa-miR-199a-3p -/0.01 3' seed miR 13 1.1285 13 0
19:54200843 C/T hsa-mir-525/hsa-miR-525-3p -/0.00 3' seed miR 1 0.0868 1 0
19:54201692 A/C hsa-miR-523-3p -/0.00 3' seed miR 3 0.2604 3 0
19:54238189 G/A hsa-mir-518d/hsa-miR-518d-3p RS73602910/0.00 3' seed miR 6 0.5208 6 0
20:33578251 A/G hsa-miR-499a-3p RS3746444/0.18 3' seed miR 358 31.0764 311 47
20:33578255 C/T hsa-miR-499a-3p RS150018420/0.00 3' seed miR 3 0.2604 3 0
22:42296995 A/G hsa-miR-33a-3p RS77809319/0.00 3' seed miR 2 0.1736 2 0
  1. Location, the location (chromosome:position, according to the human genome build GRCh37, hg19); SNV, the change observed (reference allele/alternative allele); Pre-mir/mature, the identifier of the pre-mir and the mature miRNA affected by the SNV; [dbSNP]/[1000g aaf], the dbSNP identifier and the 1000 Genomes alternative allele frequency; Region, the region in which the SNV maps within the miRNA structure (Figure 1, bottom); Number of samples, the number of samples supporting the SNV; Population frequency (%), the alternative allele frequency in the studied population; Number of heterozygous, the number of times that the SNV occurred heterozygously; Number of homozygous, the number of times that the alternative allele occurred homozygously. aThis new SNV found in hsa-mir-885/hsa-miR-885-3p was experimentally confirmed (Table 2).