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Table 3 SNVs found in all the populations analysed affecting critical regions of miRNAs

From: A map of human microRNA variation uncovers unexpectedly high levels of variability

Location

SNV

Pre-mir/mature

[dbSNP]/[1000g aaf]

Region

Number of samples

Population frequency (%)

Number of heterozygous

Number of homozygous

1:17185500

C/T

hsa-mir-3675/hsa-miR-3675-5p

RS137982850/-

5' seed miR

1

0.0868

0

1

1:100746814

A/G

hsa-mir-553/hsa-miR-553

-/0.00

5' seed miR

3

0.2604

3

0

1:176998565

T/C

hsa-miR-488-5p

-/0.00

5' seed miR

1

0.0868

1

0

3:164059159

G/A

hsa-mir-720/hsa-miR-720

-/0.00

5' seed miR

1

0.0868

1

0

4:113569088

A/G

hsa-miR-367-5p

RS150161032/0.00

5' seed miR

1

0.0868

1

0

5:140027435

C/T

hsa-mir-3655/hsa-miR-3655

RS146400503/0.01

5' seed miR

13

1.1285

13

0

7:73605546

C/T

hsa-mir-590/hsa-miR-590-5p

-/0.00

5' seed miR

4

0.3472

4

0

7:127721934

C/T

hsa-miR-593-5p

RS73721294/0.02

5' seed miR

42

3.6458

40

2

10:29891260

C/T

hsa-mir-938/hsa-miR-938

RS12416605/0.15

5' seed miR

301

26.1285

261

40

10:53059349

A/G

hsa-mir-605/hsa-miR-605

RS113212828/0.00

5' seed miR

8

0.6944

8

0

10:105807928

T/C

hsa-mir-936/hsa-miR-936

RS79924817/0.01

5' seed miR

11

0.9549

11

0

13:53384209

C/G

hsa-mir-759/hsa-miR-759

RS144233096/0.00

5' seed miR

4

0.3472

4

0

14:101520657

T/C

hsa-miR-382-5p

-/0.00

5' seed miR

1

0.0868

1

0

15:42491848

A/C

hsa-mir-627/hsa-miR-627

RS2620381/0.08

5' seed miR

157

13.6285

145

12

19:46178206

T/G

hsa-miR-642a-5p

RS78902025/0.00

5' seed miR

1

0.0868

1

0

1:3477292

C/T

hsa-mir-551a/hsa-miR-551a

-/0.00

3' seed miR

10

0.8681

10

0

1:168344829

C/T

hsa-mir-557/hsa-miR-557

RS78825966/0.06

3' seed miR

114

9.8958

98

16

2:176032384

T/C

hsa-mir-933/hsa-miR-933

RS139770589/0.00

3' seed miR

8

0.6944

8

0

3:10436198

G/Aa

hsa-mir-885/hsa-miR-885-3p

New varianta

3' seed miR

1

0.0868

1

0

3:49311593

G/C

hsa-mir-4271/hsa-miR-4271

-/0.00

3' seed miR

2

0.1736

2

0

3:160122434

G/A

hsa-miR-15b-3p

-/0.00

3' seed miR

1

0.0868

1

0

4:1988144

C/A

hsa-mir-943/hsa-miR-943

-/0.00

3' seed miR

2

0.1736

2

0

4:83674520

G/A

hsa-mir-575/hsa-miR-575

RS149186367/0.00

3' seed miR

10

0.8681

10

0

4:117220909

G/A

hsa-mir-1973/hsa-miR-1973

-/0.00

3' seed miR

1

0.0868

1

0

5:54468124

A/T

hsa-miR-449c-3p

RS35770269/0.25

3' seed miR

460

39.9306

368

92

5:148810267

C/T

hsa-miR-145-3p

-/0.00

3' seed miR

1

0.0868

1

0

5:159912418

C/G

hsa-miR-146a-3p

RS2910164/0.62

3' seed miR

933

80.9896

458

475

5:168690635

C/T

hsa-mir-585/hsa-miR-585

RS62376935/0.10

3' seed miR

199

17.2743

176

23

7:150935577

G/A

hsa-mir-671/hsa-miR-671-3p

-/0.00

3' seed miR

1

0.0868

1

0

8:10682898

A/G

hsa-mir-1322/hsa-miR-1322

-/0.00

3' seed miR

5

0.434

5

0

10:29833959

C/T

hsa-mir-604/hsa-miR-604

-/0.00

3' seed miR

3

0.2604

3

0

12:113132901

G/A

hsa-mir-1302-1/hsa-miR-1302

RS74647838/0.03

3' seed miR

53

4.6007

50

3

14:101351088

A/C

hsa-miR-136-3p

RS147448304/0.00

3' seed miR

1

0.0868

1

0

16:820249

G/A

hsa-mir-662/hsa-miR-662

RS9745376/0.05

3' seed miR

97

8.4201

87

10

16:2321809

G/A

hsa-mir-940/hsa-miR-940

RS149527765/0.00

3' seed miR

1

0.0868

1

0

18:56118358

C/T

hsa-miR-122-3p

RS41292412/0.00

3' seed miR

10

0.8681

10

0

19:2234080

G/A

hsa-mir-1227/hsa-miR-1227

RS139405773/0.00

3' seed miR

2

0.1736

2

0

19:10662866

G/A

hsa-mir-1238/hsa-miR-1238

-/0.00

3' seed miR

1

0.0868

1

0

19:10928119

A/G

hsa-mir-199a-1/hsa-miR-199a-3p

-/0.01

3' seed miR

13

1.1285

13

0

19:54200843

C/T

hsa-mir-525/hsa-miR-525-3p

-/0.00

3' seed miR

1

0.0868

1

0

19:54201692

A/C

hsa-miR-523-3p

-/0.00

3' seed miR

3

0.2604

3

0

19:54238189

G/A

hsa-mir-518d/hsa-miR-518d-3p

RS73602910/0.00

3' seed miR

6

0.5208

6

0

20:33578251

A/G

hsa-miR-499a-3p

RS3746444/0.18

3' seed miR

358

31.0764

311

47

20:33578255

C/T

hsa-miR-499a-3p

RS150018420/0.00

3' seed miR

3

0.2604

3

0

22:42296995

A/G

hsa-miR-33a-3p

RS77809319/0.00

3' seed miR

2

0.1736

2

0

  1. Location, the location (chromosome:position, according to the human genome build GRCh37, hg19); SNV, the change observed (reference allele/alternative allele); Pre-mir/mature, the identifier of the pre-mir and the mature miRNA affected by the SNV; [dbSNP]/[1000g aaf], the dbSNP identifier and the 1000 Genomes alternative allele frequency; Region, the region in which the SNV maps within the miRNA structure (Figure 1, bottom); Number of samples, the number of samples supporting the SNV; Population frequency (%), the alternative allele frequency in the studied population; Number of heterozygous, the number of times that the SNV occurred heterozygously; Number of homozygous, the number of times that the alternative allele occurred homozygously. aThis new SNV found in hsa-mir-885/hsa-miR-885-3p was experimentally confirmed (Table 2).