Effect of GHK treatment on expression in human lung fibroblasts. (a) Genes decreasing in expression with increasing regional emphysema severity were enriched among genes that are induced by GHK at 10 nM. (b) Supervised heatmaps of relative gene expression levels for the core enrichment genes in both datasets (18 genes down-regulated with Lm but up-regulated with GHK). Each gene is represented in the same row across heatmaps. (c) Genes differentially expressed with treatment of GHK at 0.1 nM were concordantly enriched among genes that change with treatment of TGFβ1. (d) Heatmap of relative gene expression levels for the core enrichment genes (118 genes up-regulated and 124 down-regulated with both GHK and TGFβ1).