Rank statistics for DHODH based on 1,000 randomizations. The x-axis indicates the rank of DHODH, the y-axis indicates the cumulative probability of observing a rank lower than that marked on the x-axis.(red) Under the recessive model DHODH ranked in the top two candidate genes in 95% of the randomizations. (blue). Under the dominant model DHODH ranked in the top seven in 95% of the randomizations.