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Table 11 MeSHOP similarity analysis of known breast cancer genes with seven or more observed mutations

From: Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles

Chromosomal location/gene(s)

Mutations observed

MeSHOP similarity rank

TP53

38

1

PIK3CA

33

55

chr17:37833600-38018803/ERBB2

21

2

GATA3

15

773

chr8:37353781-37489508/FGFR1/ZNF703

15

191/8,493

chr8:128504497-128948225/MYC

15

19

chr11:69224506-69556470/CCND1

11

9

MAP3K1

9

417

chr20:52065876-52723895/ZNF217

9

2,102

PTEN

7

12

NCOR1

7

360

CDKN2A

7

6

CDH1

7

11

  1. Genes known to be implicated in breast cancer from Supplementary Table 4 of [45] are compared to the MeSHOP similarity ranking of human genes for breast neoplasms. The rows in italics highlight genes with a MeSHOP similarity rank less than 13.