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Table 11 MeSHOP similarity analysis of known breast cancer genes with seven or more observed mutations

From: Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles

Chromosomal location/gene(s) Mutations observed MeSHOP similarity rank
TP53 38 1
PIK3CA 33 55
chr17:37833600-38018803/ERBB2 21 2
GATA3 15 773
chr8:37353781-37489508/FGFR1/ZNF703 15 191/8,493
chr8:128504497-128948225/MYC 15 19
chr11:69224506-69556470/CCND1 11 9
MAP3K1 9 417
chr20:52065876-52723895/ZNF217 9 2,102
PTEN 7 12
NCOR1 7 360
CDKN2A 7 6
CDH1 7 11
  1. Genes known to be implicated in breast cancer from Supplementary Table 4 of [45] are compared to the MeSHOP similarity ranking of human genes for breast neoplasms. The rows in italics highlight genes with a MeSHOP similarity rank less than 13.