Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles

Table 13 Datasets used in the analysis with details on size and relevant contents

Dataset	February 2007	January 2009	April 2010
Entrez Gene (including gene2pubmed and GeneRIF)
Total genes	2,460,748	4,710,910	5,999,558
Human genes	38,604	40,183	45,423
	Baseline 2007 (Nov 2006)	Baseline 2009 (Nov 2008)	Baseline 2010 (Nov 2009)
MEDLINE^®
Total articles	16,120,073	17,764,232	18,502,915
gene2pubmed (Linking Entrez Gene and MEDLINE^®
Total links	3,081,413	12,960,489	5,979,167
Total human gene links	272,123	445,650	527,821

Although the number of human genes has not increased much over the years, the number of non-human links has increased substantially since 2007, while the human gene links have increased at a more moderate rate. Previously, MEDLINE^®/PubMed^® links from genomic sequence were propagated to all related genes. This practice was discontinued in March 2009, resulting (at the time) in a 60% decrease in links and the disparity in the number of overall links from 2009 to 2010.

ISSN: 1756-994X