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Table 2 Comparison of the performance of Entrez Gene ID to gene-related literature measuresin MEDLINE®

From: Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles

  gene2pubmed GeneRIF
Feature Validation AUC (02/2007-01/2009) Validation AUC (02/2007-04/2010) CTD validation (11/2008) Validation AUC (02/2007-01/2008) Validation AUC (02/2007-04/2010) CTD validation (11/2008)
Number of MeSH terms 0.74 0.73 0.81 0.80 0.85 0.82
Number of publications 0.75 0.73 0.80 0.80 0.85 0.82
Oldest publication (year) 0.67 0.66 0.73 0.73 0.76 0.73
Gene ID 0.64 0.64 0.66 0.69 0.75 0.73
  1. The oldest publication for a gene has comparable performance to Entrez Gene ID, as measured by the AUC; however, the number of publications for a gene proves to be even more predictive than the Entrez Gene ID.