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Figure 7 | Genome Medicine

Figure 7

From: Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival

Figure 7

CGH profiles for GNS lines. Dots indicate log2 ratios for array CGH probes along the genome, comparing each GNS cell line to normal female DNA. Colored segments indicate gain (red) and loss (green) calls, with color intensity proportional to mean log2 ratio over the segment. Aberrations known to be common in glioblastoma [11, 79] were identified, including gain of chromosome 7 and losses of large parts of chromosomes 10, 13, 14 and 19 in more than one GNS cell line, as well as focal gain of CDK4 in G144 (arrow, chromosome 12) and focal loss of the CDKN2A-CDKN2B locus in G179 (arrow, chromosome 9). The X chromosome was called as lost in G144 and G179 because these two cell lines are from male patients; sex-linked genes were excluded from downstream analyses of aberration calls.

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