Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival

Table 2 Selected Gene Ontology terms and InterPro domains enriched among differentially expressed genes

	Differentially expressed (729 genes)		Upregulated (485 genes)		Downregulated (254 genes)
	Genes	P	Genes	P	Genes	P
Biological process Gene Ontology terms
Immune response	70	2.4 × 10^-12	61	3.0 × 10^-16	9	NS
Nervous system development	106	1.9 × 10^-10	62	0.0055	44	2.3 × 10^-5
Cell adhesion	74	9.8 × 10^-8	56	1.9 × 10^-7	18	NS
Antigen processing and presentation	17	4.3 × 10^-7	17	5.4 × 10^-10	0	NS
Cell differentiation	128	7.4 × 10^-7	74	NS	54	1.8 × 10^-4
Cell migration	44	3.0 × 10^-4	30	0.0262	14	NS
Cell proliferation	86	3.4 × 10^-4	59	0.0136	27	NS
Cellular ion homeostasis	36	0.0138	33	1.7 × 10^-5	3	NS
Molecular function Gene Ontology terms
Cytokine activity	27	2.3 × 10^-8	25	7.1 × 10^-11	2	NS
Signal transducer activity	111	2.8 × 10^-7	66	0.0584	45	0.0017
Receptor activity	83	8.0 × 10^-7	48	NS	35	0.0016
Sequence-specific DNA binding	52	2.7 × 10^-4	34	0.0526	18	NS
MHC class II receptor activity	5	0.0077	5	9.2 × 10^-4	0	NS
Growth factor activity	20	0.0109	17	0.0019	3	NS
InterPro domains
Immunoglobulin-like	45	3.1 × 10^-8	32	6.0 × 10^-6	13	NS
MHC classes I/II-like antigen recognition protein	14	1.1 × 10^-7	14	3.2 × 10^-10	0	NS
Homeobox	28	8.5 × 10^-6	18	0.0124	10	NS

Number of genes differentially expressed at 10% FDR and annotated with the indicated Gene Ontology and InterPro terms. P-values indicating the statistical significance of enrichment of these terms were computed with Fisher's exact test and corrected for multiple testing using the Bonferroni method. NS, not significant (P > 0.1).

ISSN: 1756-994X