Figure 5
From: Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines
Mapping of genomic alterations in three cell lines to most basic signaling pathways from the KEGG database, KEGG cancer super-pathway 05200, and the group of 623 genes associated with cancer by Ding et al.[42]. Yellow boxes, U251MG; blue boxes, A431; purple boxes, U2OS. A single line summarizes the network connections between each pair of gene sets, with the line's width reflecting the number of links in the global network connecting individual genes from the two functional gene sets (3...189). Only relations significant by NEA are shown (P-value <0.05, FDR <0.10). Edge opacity and edge width reflect the number of individual gene-gene links behind the relation (also printed in brown at each edge). Mapping between experimentally determined gene sets of cell lines is highlighted in red. AI, allelic imbalance; MTOR, mammalian target of rapamycin; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.