Table 2 LS-SVM models for the prediction of WHEELER, pN-STAGE and CRM in rectal cancer
From: A kernel-based integration of genome-wide data for clinical decision support
| Outcome | Model | NG* | NP† | AUC (SE)‡ | p-value§ |
|---|---|---|---|---|---|
| WHEELER | |||||
| A | MT 0 | 4 | 0.7538 (0.1085) | 0.0987 | |
| MT 1 | 29 | 0.9038 (0.0502) | 0.6861 | ||
| PT 0 | 35 | 0.7423 (0.0867) | 0.0540 | ||
| PT 1 | 11 | 0.9038 (0.0575) | 0.7273 | ||
| B | MT0-T1 | 32 | 0.6846 (0.1215) | 0.0598 | |
| PT0-T1 | 5 | 0.8654 (0.0621) | 0.4135 | ||
| C | MT 01 | 3¶ | 0.7808 (0.0985) | 0.1320 | |
| PT 01 | 21¶ | 0.7692 (0.0831) | 0.0831 | ||
| MPT 0 | 3 | 35 | 0.8461 (0.0718) | 0.2760 | |
| MPT 1 | 25 | 12 | 0.9269 (0.0425) | ||
| MPT 01 | 2¶ | 31¶ | 0.8846 (0.0558) | 0.4858 | |
| MT 0 PT 1 | 2 | 4 | 0.9385 (0.0444) | 0.8101¥ | |
| pN-STAGE | |||||
| A | MT 0 | 25 | 0.6493 (0.0914) | 2.315e-4 | |
| MT 1 | 22 | 0.8506 (0.0665) | 0.0362 | ||
| PT 0 | 2 | 0.6753 (0.0906) | 6.659e-4 | ||
| PT 1 | 12 | 0.8409 (0.0652) | 0.0238 | ||
| B | MT0-T1 | 4 | 0.6071 (0.0986) | 1.359e-4 | |
| PT0-T1 | 9 | 0.7662 (0.0900) | 0.0153 | ||
| C | MT 01 | 24¶ | 0.9286 (0.0450) | 0.1998 | |
| PT 01 | 34¶ | 0.8182 (0.0695) | 0.0145 | ||
| MPT 0 | 27 | 27 | 0.9188 (0.0469) | 0.1591 | |
| MPT 1 | 21 | 14 | 0.9870 (0.0135) | ||
| MPT 01 | 23¶ | 16¶ | 0.9610 (0.0280) | 0.3421 | |
| MT 0 PT 01 | 26 | 20¶ | 1 (0) | 0.3347¥ | |
| CRM | |||||
| A | MT 0 | 33 | 0.6790 (0.1016) | 0.0072 | |
| MT 1 | 9 | 0.9259 (0.0472) | 0.4955 | ||
| PT 0 | 34 | 0.8518 (0.0624) | 0.0935 | ||
| PT 1 | 34 | 0.7654 (0.0831) | 0.0281 | ||
| B | MT0-T1 | 6 | 0.9136 (0.0480) | 0.4030 | |
| PT0-T1 | 2 | 0.8272 (0.0709) | 0.0849 | ||
| C | MT 01 | 16¶ | 0.8066 (0.0846) | 0.0468 | |
| PT 01 | 3¶ | 0.7531 (0.0865) | 0.0227 | ||
| MPT 0 | 7 | 27 | 0.8477 (0.0688) | 0.1340 | |
| MPT 1 | 7 | 33 | 0.9630 (0.0344) | ||
| MPT 01 | 2¶ | 3¶ | 0.8230 (0.0771) | 0.0973 | |
| MT 1 PT 0 | 16 | 14 | 0.9630 (0.0376) | 1 | |
| MT 01 PT 1 | 9¶ | 29 | 0.9876 (0.0146) | 0.4924¥ |