Skip to main content

Table 3 Features for (colo)rectal cancer selected by MPT1 and known to be involved in this type of cancer

From: A kernel-based integration of genome-wide data for clinical decision support

Outcome*

Gene/protein

Hits†

Region

Function

Up/down‡

Reference

W

Cox-2

36

1q25.2-q25.3

Progression

Up

[50]

W

IL-1B

36

2q14

Inflammatory response

Up

[50]

W

Ferritin

36

11q13; 19q13.3-q13.4

Iron storage

Down

[63]

W

EGF

36

4q25

Cell growth/proliferation/differentiation

Up

[64]

W

MMP-2

36

16q13-q21

Invasion/metastasis

Up

[65]

W

TGFα

36

2p13

Angiogenesis/cell proliferation

Down

[51]

W

SELE

25

1q22-q25

Progression/metastasis

Up

[66]

W

GM-CSF

24

5q31.1

Maintenance of granulocytes/macrophages

Up

[67]

W

MMP-1

15

11q22.3

Tumor invasion/metastasis/poor prognosis

Up

[68]

N

Reg4

36

1p13.1-p12

Early carcinogenesis

Down

[69]

N

MUC2

36

11p15.5

Deregulated by TNFα

Down

[70]

N

CA1

36

8q13-q22.1

Carbonate dehydratase activity

Down

[71]

N

CA2

36

8q22

Carbonate dehydratase activity

Down

[71]

N

CLDN8

36

21q22.11

Tumorigenesis

Down

[72]

N

CEA

36

19q13.1-q13.2

Cell adhesion; tumor marker for recurrence

Down

[53]

N

IL-1ra

36

2q14.2

Carcinogenesis

Up

[73]

N

CA19-9

36

 

Tumor marker for recurrence

Down

[53]

N

Ferritin

36

11q13; 19q13.3-q13.4

Iron storage

Down

[63]

N

IL-1beta

36

2q14

Inflammatory response

Down

[50]

N

beta2-microglobulin

36

15q21-q22.2

Metastasis

Up

[74]

N

RARRES1

31

3q25.32-q25.33

Cell proliferation

Down

[75]

N

IL-8

28

4q13-q21

Progression/metastasis

Down

[52]

N

TNFRII

24

1p36.3-p36.2

Apoptosis

Up

[76]

C

ICAM-1

36

19p13.3-p13.2

Metastasis

Down

[77]

C

CEA

36

19q13.1-q13.2

Cell adhesion; tumor marker for recurrence

Down

[53]

C

MMP-2

36

16q13-q21

Invasion/metastasis

Up

[65]

C

Adiponectin

36

3q27

Metabolic/hormonal processes

Down

[78]

C

Thrombospondin-1

36

15q15

Angiogenesis/tumor growth

Up

[79]

C

EGFR

36

7p12

Cell growth/proliferation/differentiation

Up

[49]

C

Tissue factor

35

1p22-p21

Angiogenesis/metastasis

Up

[80]

C

CYP1B1

35

2p21

Drug metabolism

Down

[81]

C

EGF

32

4q25

Cell growth/proliferation/differentiation

Up

[64]

  1. *W, WHEELER; N, pN-STAGE; C, CRM. †Number of occurrences of the gene/protein in the 36 LOO iterations. ‡Up/down-regulation in the good responders with respect to moderate or poor responders; no lymph nodes with respect to at least one regional lymph node; negative CRM with respect to positive CRM. CRC, (colo)rectal cancer.