From: A kernel-based integration of genome-wide data for clinical decision support
Outcome* | Gene/protein | Hits†| Region | Function | Up/down‡ | Reference |
---|---|---|---|---|---|---|
W | Cox-2 | 36 | 1q25.2-q25.3 | Progression | Up | [50] |
W | IL-1B | 36 | 2q14 | Inflammatory response | Up | [50] |
W | Ferritin | 36 | 11q13; 19q13.3-q13.4 | Iron storage | Down | [63] |
W | EGF | 36 | 4q25 | Cell growth/proliferation/differentiation | Up | [64] |
W | MMP-2 | 36 | 16q13-q21 | Invasion/metastasis | Up | [65] |
W | TGFα | 36 | 2p13 | Angiogenesis/cell proliferation | Down | [51] |
W | SELE | 25 | 1q22-q25 | Progression/metastasis | Up | [66] |
W | GM-CSF | 24 | 5q31.1 | Maintenance of granulocytes/macrophages | Up | [67] |
W | MMP-1 | 15 | 11q22.3 | Tumor invasion/metastasis/poor prognosis | Up | [68] |
N | Reg4 | 36 | 1p13.1-p12 | Early carcinogenesis | Down | [69] |
N | MUC2 | 36 | 11p15.5 | Deregulated by TNFα | Down | [70] |
N | CA1 | 36 | 8q13-q22.1 | Carbonate dehydratase activity | Down | [71] |
N | CA2 | 36 | 8q22 | Carbonate dehydratase activity | Down | [71] |
N | CLDN8 | 36 | 21q22.11 | Tumorigenesis | Down | [72] |
N | CEA | 36 | 19q13.1-q13.2 | Cell adhesion; tumor marker for recurrence | Down | [53] |
N | IL-1ra | 36 | 2q14.2 | Carcinogenesis | Up | [73] |
N | CA19-9 | 36 | Â | Tumor marker for recurrence | Down | [53] |
N | Ferritin | 36 | 11q13; 19q13.3-q13.4 | Iron storage | Down | [63] |
N | IL-1beta | 36 | 2q14 | Inflammatory response | Down | [50] |
N | beta2-microglobulin | 36 | 15q21-q22.2 | Metastasis | Up | [74] |
N | RARRES1 | 31 | 3q25.32-q25.33 | Cell proliferation | Down | [75] |
N | IL-8 | 28 | 4q13-q21 | Progression/metastasis | Down | [52] |
N | TNFRII | 24 | 1p36.3-p36.2 | Apoptosis | Up | [76] |
C | ICAM-1 | 36 | 19p13.3-p13.2 | Metastasis | Down | [77] |
C | CEA | 36 | 19q13.1-q13.2 | Cell adhesion; tumor marker for recurrence | Down | [53] |
C | MMP-2 | 36 | 16q13-q21 | Invasion/metastasis | Up | [65] |
C | Adiponectin | 36 | 3q27 | Metabolic/hormonal processes | Down | [78] |
C | Thrombospondin-1 | 36 | 15q15 | Angiogenesis/tumor growth | Up | [79] |
C | EGFR | 36 | 7p12 | Cell growth/proliferation/differentiation | Up | [49] |
C | Tissue factor | 35 | 1p22-p21 | Angiogenesis/metastasis | Up | [80] |
C | CYP1B1 | 35 | 2p21 | Drug metabolism | Down | [81] |
C | EGF | 32 | 4q25 | Cell growth/proliferation/differentiation | Up | [64] |