Figure 2

Outline of the method to transform the scores. (a) Functional impact scores (FISs) of all germline single nucleotide variants (SNVs) from the 1000 Genomes Project are computed. (b) SNVs are partitioned into subsets according to the category of the genes that harbor them (for example, Gene Ontology Molecular Function). (c) FISs of a given cancer somatic mutation are computed and transformed using the distribution of the scores of SNVs in the same category as the protein where the mutation under analysis occurs. We give these transformed scores the generic name transFIC (transformed Functional Impact scores in Cancer).