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Figure 3 | Genome Medicine

Figure 3

From: Improving the prediction of the functional impact of cancer mutations by baseline tolerance transformation

Figure 3

Transformed Functional Impact for Cancer (transFIC) systematically outperforms original scores in the task of differentiating cancer driver mutations from neutral variants. (a) Performance of GOMF transFIC is compared to the three original functional impact scores (FISs) classifying the nine proxy datasets, using as cutoff the value of FIS (or transFIC) that maximizes the Mathews correlation coefficient (MCC) in each case. (b) Performance of GOMF transFIC is compared to the original score of CHASM (q-value cutoff <0.05) in two proxy datasets after removal of mutations within the training set of CHASM.

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Genome Medicine

ISSN: 1756-994X

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