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Table 3 Proteinogenic amino acids in serum of healthy volunteers treated with prednisolone.

From: Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling

Metabolite

Day 2

Day 16

Name

HMDB ID

Placebo

30 mg

75 mg

Placebo

30 mg

L-glutamine

HMDB00641

1.1

1.4

1.6***

1.5

1.4

L-alanine

HMDB00161

1.1

1.3**

1.5***

1.2

1.3

L-asparagine

HMDB00168

1.2

1.3

1.5**

1.2

1.2

L-arginine

HMDB00517

1.3

1.0

1.4*

1.5

1.1

L-aspartic acid

HMDB00191

1.2

1.1

1.4*

1.3

1.1

L-phenylalanine

HMDB00159

1.1

1.1

1.2**

1.1

1.0

L-proline

HMDB00162

1.1

1.1

1.2**

1.2

1.2

L-threonine

HMDB00167

1.1

1.1

1.2**

1.1

1.0

L-tyrosine

HMDB00158

1.2

1.1

1.2*

1.1

1.0

L-tryptophan

HMDB00929

1.1

1.2

1.1*

1.2

1.1

L-serine

HMDB00187

1.2

1.1

1.3

1.2

1.0

L-histidine

HMDB00177

1.1

1.0

1.1

1.1

0.9

L-isoleucine

HMDB00172

1.1

1.1

1.1

1.0

0.9

L-lysine

HMDB00182

1.2

1.0

1.1

1.1

1.0

L-glutamic acid

HMDB00148

1.1

0.9

1.0

1.1

1.0

L-leucine

HMDB00687

1.1

1.0

1.0

1.0

0.8

L-valine

HMDB00883

1.1

0.9

0.9

1.0

0.9

  1. Data represents the mean ratio of metabolite level at day 2 or day 16 compared with day 1. *P <0.05, **P <0.01,***P <0.001 and q <0.05 compared to placebo group for protocol 1 using liner mixed models, and compared to day 0 for protocol 2, using paired t tests. HMDB, Human Metabolome Database.