Skip to main content

Table 1 Common SNPs across the IL28B gene region and their haplotypes

From: Pharmacogenomics of hepatitis C infections: personalizing therapy

Location

SNP

Haplotype

  

1a

2b

3

4a

5

6

5'

rs7248668

G

A

G

G

G

G

5'

rs8099917c

T

G

T

T

T

T

5'

rs8109886

C

A

A

A

A

A

5', CpG

rs4803221

C

G

C

C

C

G

5', CpG

rs12979860c

C

T

T

C

T

T

Exon 2

rs8103142

T

C

C

T

C

C

Intron 2

rs11881222

A

G

G

A

A

G

3'

rs688187

G

A

A

G

A

A

3'

rs8105790

T

C

C

T

T

C

3'

rs12982533

T

C

C

T

T

C

3'

rs12980275

A

G

G

A

A

G

OR (95% CI)

0.70

(0.57-0.85)

2.20

(1.72-2.80)

1.04

(0.75-1.43)

0.60

(0.43-0.83)

0.79

(0.39-1.60)

1.49

(0.62-3.56)

%CEU (CHC)

43.2

23.8

10.3

9.8

1.9

1.4

  1. aHighest sustained viral response. bCausal haplotype; lowest sustained viral response. cSNPs currently used for genotyping to decide CHC treatment. Odds ratio (OR) and percentage of haplotypes in chronic hepatitis C (CHC) in patients of European descent (CEU) are from Smith et al. [20]. CI, confidence interval.
Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us