Pharmacogenomics of hepatitis C infections: personalizing therapy

Table 2 Common SNPs across the IL28B gene region have very different minor allele frequencies in the major ethnic groups

Location	SNP	OR	%CEU	%CHI	%YRI
5'	rs7248668	2.24^b	17	7	6
5'	rs8099917^c	1.91^b	17	8	6
5'	rs8109886	0.67^a	43	7	80
5', CpG	rs4803221	2.24^b	17	7	18
5', CpG	rs12979860^c	1.99^b	32	8	60
Exon 2	rs8103142	1.50^b	27	4	56
Intron 2	rs11881222	2.02^b	30	7	31
3'	rs688187	1.94^b	32	7	59
3'	rs8105790	1.63^b	17	7	19
3'	rs12982533	2.01^b	31	8	39
3'	rs12980275	1.79^b	31	8	51

^aMinor allele predicts treatment success. ^bMinor allele predicts treatment failure. ^cSNPs currently used in genotyping to decide treatment for CHC. %, Percentage of SNPs in major ethnic groups. CEU, European; CHI, Han Chinese; YRI, Yorubi Africans. SNP frequencies are from the 1000 Genome Project pilot genotyping data.

ISSN: 1756-994X