Genome-wide copy-number analysis in malignant melanoma (MM) and its association with repetitive-element methylation. (A) Summary of the results of array comparative genomic hybridization (aCGH) analyses in MM (n = 67) and monoclonal gammopathy of undetermined significance (MGUS; n = 6). Loss frequencies(green) are shown on the left, and gain (orange) on the right. (B) Unsupervised hierarchical clustering of the MM and MGUS samples using the aCGH data. Color scales represent genomic loss (green), gain (orange) and no change (light blue) in copy number. The heat map shown underneath indicates the methylation levels of the indicated repetitive elements.