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Table 1 List of common breakpoints

From: Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma

Chr. Locus Start End LINE-1 density
(per 100,000 bp)
Gene Break frequency, % Chr. Locus Start End LINE-1 density
(per 100000bp
Gene Break frequency, %
1 p34.2 41313735 41355091 58.03 SCMH1 10.4 10 q25.1 111391808 111534660 37.1   6.0
1 p34.2 41479154 41520306 21.87   11.9 10 q25.3 116921563 116965495 106.98 ATRNL1 10.4
1 p31.3 63102450 63125693 25.81   9.0 10 q25.3 117395507 117462466 37.34 ATRNL1 9.0
1 q21.1 145031426 145108225 54.69 PRKAB2 6.0 11 p13 36266146 36292214 57.54   6.0
2 p23.2 27659776 28122129 48.23 BRE 6.0 11 q23.3 117486844 117510539 84.41 SCN4B 14.9
2 p15 63302135 63367996 65.29 C2orf86 9.0 12 p13.2 11222379 11312714 55.35 PRB3 6.0
2 p11.2 88925032 88984458 53.85   6.0 12 p12.3 15020696 15041656 57.25   7.5
2 q11.2 96394039 96423431 47.63   13.4 12 p11.21 30798016 30861280 41.1   9.0
2 q14.2 118022882 119843354 27.52 DBI 7.5 12 q12 34236852 36858944 7.09   6.0
3 p24.2 25637260 25664255 25.93 TOP2B 16.4 12 q13.2 53311891 53382664 35.32   16.4
3 p24.2 25799317 25810811 8.7 OXSM 10.4 12 q13.2 54253884 54290994 40.42   13.4
3 p24.2 25810870 25997134 29.53   10.4 12 q14.1 56621139 56633663 7.98 XRCC6BP1 9.0
3 q11.2 90336752 95063426 1.23   6.0 12 q21.33 90946754 91022602 21.09   7.5
3 q26.1 163874118 163997228 33.3   47.8 13 q14.11 43044213 43114392 45.6 ENOX1 11.9
4 q23 99907678 100011201 56.99   6.0 13 q14.11 43114451 43143651 10.27 ENOX1 11.9
4 q31.3 152038958 152092912 48.19 LRBA 7.5 14 q22.1 48984150 49093570 25.59   6.0
4 q31.3 153097317 153228047 17.59   7.5 14 q31.3 88397409 88411102 51.12 TTC8 9.0
4 q34.1 174459916 174490317 23.03 HMGB2 6.0 14 q32.33 105080399 105354886 21.86 IgH 19.4
5 q13.3 75888651 75947525 25.48 IQGAP2, F2RL2 7.5 14 q32.33 105469384 105481523 57.67 IgH 11.9
        14 q32.33 105787449 105834932 86.35 IgH 9.0
5 q13.3 76284777 76301015 0 CRHBP 7.5 14 q32.33 105947052 105977946 61.5 IgH 16.4
5 q31.3 140094857 140166875 59.71 PCDHA1/2/3 7.5 15 q22.2 59803190 59933103 24.63 VPS13C 6.0
5 q33.3 157216334 157301114 41.28   9.0 15 q24.3 74558533 74601045 56.45 SCAPER 9.0
5 q34 162798715 162800093 0 CCNG1 9.0 16 q11.2 34083801 45122058 2.98 FLJ43980 6.0
5 q34 162818326 162833628 19.61 HMMR 11.9 17 q12 35221880 35241893 9.99 IKZF3 11.9
5 q35.1 170161782 170195254 8.96   7.5 17 q12 35282145 35316098 55.96 GSDMB 16.4
5 q35.1 170596026 170659586 33.04 RANBP17 6.0 17 q21.2 36666037 36724675 28.99 KRTAP17-1 6.0
6 q11.1 62760108 62854732 38.05 KHDRBS2 9.0 17 q21.31 38255982 38261676 17.56 AOC3 7.5
6 q26 162822332 162896532 9.43 PARK2 7.5 17 q25.1 71511380 71527979 0 EVPL 6.0
6 q27 166369554 166405962 52.19   7.5 19 q13.12 40328372 40338038 0 FXYD5 7.5
7 p15.3 20788779 20857393 14.57   6.0 19 q13.42 61045704 61062298 66.29 NLRP4 20.9
7 p14.1 39890729 39952510 58.27   6.0 20 p13 3365914 3411271 59.53 ATRN 9.0
7 p14.1 40008069 40034702 45.06 CDC2L5 6.0 20 p13 3553255 3588125 43.02 GFRA4 9.0
7 q31.2 116015401 116093417 15.38   11.9 20 q12 40298330 40332059 0 PTPRT 22.4
7 q35 147108655 147152043 27.66 CNTNAP2 6.0 20 q13.12 43765836 43768958 0 WFDC13 6.0
8 q12.1 59427474 59488208 41.16 UBXN2B 7.5 20 q13.32 57813291 57856200 9.32   9.0
8 q12.1 59519371 59565778 15.08 CYP7A1 7.5 20 q13.33 58011342 58074892 33.04 C20orf197 7.5
8 q24.3 145297206 145464363 45.47 BOP1 13.4 21 q22.11 31050355 31088151 10.58   6.0
9 p23 11563590 11687635 54.01   6.0 22 q11.22 21520273 21588229 38.26 IgL 6.0
9 q21.33 87357577 87392381 51.72 AGTPBP1 9.0 22 q12.3 34602119 34638273 0 RBM9 6.0
10 q25.1 109269991 109444702 43.5   6.0        
  1. long interspersed nuclear element-1 (LINE-1)