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Figure 1 | Genome Medicine

Figure 1

From: HLA typing from RNA-Seq sequence reads

Figure 1

HLA sequence variability. (a) The helices encoded by exons 2 (α1- chain: orange) and 3 (α2-chain: red) of the HLA class I alleles bind peptides (crystal structure 3OXR from PDB). (b) HLA locus is polygenic (A, B, C) and highly polymorphic within and across the three class I genes, showing the nucleotide variability at each position of a multiple sequence alignment of all HLA class I alleles, where 0 and 2 represent minimum and maximum variability, as defined using Shannon's Entropy (2 - Information Content; see Methods). (c) Example sequences are shown for four regions in seven HLA groups.

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