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Table 1 Multivariate analysis of hepatic OATP expression in relation to 10 non-genetic factors in the total sample set of 143 human livers

From: Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

 

P-value

Non-genetic factor

SLCO1B1mRNA

OATP1B1 protein

SLCO1B3mRNA

OATP1B3 protein

SLCO2B1mRNA

OATP2B1 protein

Sex

0.903

0.766

0.661

0.463

0.623

0.072

Age

0.502

0.630

0.466

0.060

0.711

0.947

Smoking habit

0.534

0.454

0.173

0.731

0.214

0.278

Alcohol consumption

0.037

0.124

0.076

0.904

0.001

0.206

Pre-surgery drugs

0.294

0.786

0.638

0.401

0.567

0.168

Diagnosis

0.458

0.046

0.238

0.101

0.506

0.066

Bilirubin

0.846

0.108

0.348

0.194

0.997

0.847

γ-Glutamyl transferase

0.363

0.820

0.548

0.448

0.461

0.547

Cholestasis

0.286

0.020

0.008

0.021

0.467

0.232

C-reactive protein

0.039

0.070

0.873

0.132

0.520

0.466