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Table 2 Multivariate analysis of the miRNA prognostic power adjusting for the effect of known prognostic factors

From: MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32

Univariate hazard ratio
(5 miRNA profile)
P Multivariate hazard ratio
(5 miRNA profile)
P
2.66 (1.12 to 6.30) 0.02 Controlling for chemoresponse 2.67 0.026
   Controlling for metastases at diagnosis 2.40 0.05
  1. Tumor site was not prognostic due to the overwhelming majority of tumors located in the extremities, and preoperative chemotherapy regimen was confounded by the presence of metastasis at diagnosis.