Type of toxicity | Drug | HLA allele | Type of study | Approximate odds ratio | Reference(s) |
---|---|---|---|---|---|
Hypersensitivity | Abacavir | B*57:01 | Candidate gene | 800 | |
Liver injury | Amoxicillin-clavulanate | DRB1*15:01-DQB1*06:02 A*02:01 | Candidate gene and GWA | 3 2.3 | |
 | Ximelagatran | DRB1*07:01-DQA1*02:01 | GWA | Not available (P = 6.0 × 10-6) | [95] |
 | Ticlopidine | A*33:03 | Candidate gene | 13 | [96] |
 | Flucloxacillin | B*57:01 | GWA | 80 | [17] |
 | Lumiracoxib | DRB1*15:01-DQB1*06:02 | GWA | 5.3 | [97] |
 | Lapatinib | DQA1*02:01 | GWA and candidate gene | 9 | [98] |
 | Nevirapine | DRB1*01 | Candidate gene | 3 | |
SJS and TEN | Carbamazepine | B*15:02 | Candidate gene | 895 | [21] |
Various skin reactions, including SJS and TEN | Carbamezepine | A*31:01 | GWA | 12 | |
Various skin reactions including SJS and TEN | Allopurinol | B*58:01 | Candidate gene | 400 | [29] |
Various skin reactions | Nevirapine | B*35:05 Cw*8 Cw*04 | Candidate gene and GWA | 30 15 2.5 | [35] |