Pharmacogenomics of adverse drug reactions

Table 2 Drug disposition genes and adverse drug reactions

Gene	Reaction	Drug	Type of study	Reference(s)
Phase I drug metabolism
CYP2B6	Skin rash	Nevirapine	Candidate gene	[29]
Phase II drug metabolism
NAT2	DILI	Isoniazid	Candidate gene	[100–110]
UGT1A	DILI	Tolcapone	Candidate gene	[56]
UGT2B7	DILI	Diclofenac	Candidate gene	[57]
UGT1A	DILI	Various	GWA	[18]
Drug transporters
SLCO1B1	Myopathy	Simvastatin	GWA	[48]
ABCB11	DILI	Various	Candidate gene	[60]
ABCC2	DILI	Diclofenac	Candidate gene	[57]
	DILI	Various	Candidate gene	[63]
	DILI	Various	GWA	[18]

ISSN: 1756-994X