Figure 2From: Genes and epigenetic processes as prospective pain targetsEvidence for epigenetic modulation in pain. Evidence has been obtained for such modulation at four different levels, numbered here in order from peripheral to central. 1, Pain-associated hyperacetylation of MIP2 and CXCR5 in the nerve after partial sciatic nerve ligation (PSL) [86] (shown in yellow). 2, Decreased expression of MeCP2 target genes after CFA [91]; miRNA expression changes [104, 106]; intrathecal HDAC inhibitor treatment reduces acute pain after CFA [83] (shown in green). 3, GAD2 hypoacetylation after CFA leads to loss of descending inhibition [84] (shown in pink). 4, Carrageenan-associated miRNA dysregulation in the prefrontal cortex [105] (shown in purple).Back to article page