Figure 3
From: Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma
Association at the GCKR locus. SNP rs780094 (and SNPs in LD) have been associated with different diabetes-relevant traits, including fasting glucose and triglyceride levels (TG). We observe a genome-wide significant association (P = 2.8x10-15) at this locus with the ratio of intensities at δ = 3.286 ppm and δ = 1.370 ppm (dashed lines) (Table 1). The correlation spectra for glucose and TG (both parameters were determined by clinical biochemistry) show that the association signal at δ = 3.286 ppm is mainly driven by glucose and that at δ = 1.370 ppm by TG. The ratio of these two NMR intensities is thus a likely proxy for a diabetes-relevant composite readout on the GCKR pathway.