Table 2 Comparison with association data from previous studies on the same specimen.
From: Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma
Locus | Mass spectrometry Non-targeted, semi-quantitative[5] | NMR Lipid subclasses[13] | NMR Ratios between chemical shifts(this study) | ||
|---|---|---|---|---|---|
GCKR | Trait | Pc ae C34:2/Pc aa C32:2 | Glucose/Mannose | L10 | 3.286 ppm/1.370 ppm |
SNP | rs1260326, LD r2 = 0.93 | rs780094 | rs1260326, LD r2 = 0.93 | rs780094 | |
P value | P = 3.8x10-8 | P = 4.9x10-32 | P = 3.7x10-6 | P = 2.8x10-15 | |
CPS1 | Trait | Glycine/PC aa C38:2 | Asparagine/Glycine | 3.599 ppm/2.475 ppm | |
SNP | rs2216405 | rs2216405 | (locus not reported) | rs2216405 | |
P value | P = 1.9x10-30 | P = 9.8x10-21 | P = 1.8x10-19 | ||
PYROXD2 | Trait | Saccharin/Threonine | 2.757 ppm/2.755 ppm | ||
SNP | (locus not reported) | rs4488133 | (locus not reported) | rs4488133 | |
P value | P = 0.00021 | P = 2.9x10-94 | |||
FADS1 | Trait | PC aa C36:3/PC aa C36:4 | 1-arachidonoylglycero-phosphoethanolamine/1-linoleoylglycero-phosphoethanolamine | L4 | 2.801 ppm/2.017 ppm |
SNP | rs174547 | rs174547 | rs174546, LD r2 = 1.0 | rs174547 | |
P value | P = 6.5x10-179 | P = 1.2x10-80 | P = 1.4x10-5 | P = 1.1x10-94 | |
APOA1 | Trait | PC aa C36:2/PC aa C38:1 | 1-oleoglycerol/Oleamide | L8 | 4.162 ppm/4.082 ppm |
SNP | rs964184, LD r2 = 0.61 | rs3741298 | rs964184, LD r2 = 0.61 | rs3741298 | |
P value | P = 1.8x10-10 | P = 4.3x10-7 | P = 4.8x10-12 | P = 1.8x10-14 | |
LIPC | Trait | PCaa C38:6 | 1-palmitoylglycero-phosphoethanolamine | L5 | 1.068 ppm/1.029 ppm |
SNP | rs4775041 | rs4775041 | rs1532085, LD r2 = 0.55 | rs4775041 | |
P value | P = 9.7x10-8 | P = 8.7x10-7 | P = 5.3x10-11 | P = 3.6x10-21 | |
CETP | Trait | Guanosine/Phenylacetylglutamine | L3 | 2.211 ppm/2.011 ppm | |
SNP | (locus not reported) | rs247617 | rs3764261, LD r2 = 1.0 | rs247617 | |
P value | P = 0.00039 | P = 3.6x10-7 | P = 1.1x10-18 |