Table 3 Spearmancorrelations between NMR intensities and metabolic traits determined by MS and clinical biochemistry.
From: Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma
Locus | SNP | Chemical shift (ppm) | Metabolite | rs2 | Chemical shifts for ratios (ppm) | Metabolite or Metabolite ratios | rs2 |
|---|---|---|---|---|---|---|---|
GCKR | rs780094 | 1.370 | Triglyceride | 0.62 | 3.286/1.370 | Glucose/Triglyceride | 0.42 |
CPS1 | rs2216405 | 3.599 | Glycine | 0.22 | 3.599/2.475 | Glycine/Tryptophan | 0.29 |
PYROXD2 | rs4488133 | 2.757 | Total cholesterol | 0.64 | 2.757/2.755 | Total cholesterol/Triglyceride | 0.26 |
FADS1 | rs174547 | 2.801 | PC aa C38:5 | 0.48 | 2.801/2.017 | PC aa C38:5/ PC aa C36:3 | 0.45 |
APOA1 | rs3741298 | 2.038 | Triglyceride | 0.73 | 4.162/4.082 | Lactate/Triglyceride | 0.60 |
LIPC | rs4775041 | 1.283 | PC aa C36:1 | 0.42 | 1.068/1.029 | 4-methyl-2-oxopentanoate/Total cholesterol | 0.21 |
CETP | rs247617 | 3.259 | HDL cholesterol | 0.55 | 2.211/2.011 | HDL cholesterol | 0.68 |