Integration of DNA-methylation data with public gene-expression data. (A) DNA methylation correlates with decreased gene expression: scatter plot of t-statistics between human papillomavirus-positive (HPV+) and HPV-negative (HPV-) formalin-fixed, paraffin wax-embedded (FFPE) cancer samples (top 500 differentially methylated MVPs restricted to CpG islands) shows significant anti-correlation between DNA methylation and gene expression. Gene expression-data were taken from Pyeon et al., . (B) List of top 10 anti-correlated targets: Differentially methylated genes in promoter region (TSS200) which also exhibit differential gene expression in the independent Pyeon gene-expression dataset. 3 Cadherin genes were found among the top 10 hits (bold).