Category | Current study | Kitzman et al. | Fan et al. | ||||
---|---|---|---|---|---|---|---|
 |  |  | Trio I1 | Trio G1 | P1T1 | P1T2 | P2T3 |
Gestational week | 13 | 18.5 | 8.14 | 9 | 29 | 39 | |
Estimated average cff-DNA concentration | 5.69% | 13%a | 6%a | 6%a | 16%a | 30%a | |
Average sequence depth (fold) | 43.91 | 78a,b | 56a,b | 52.7 | 20.8 | 10.7 | |
Fetal gender | Male | Male | - | Female | Female | Female | |
Maternal allele | Â | Â | Â | Â | Â | Â | |
Predicted rate | 100% | 91.4% | - | >99.2% | |||
Predictionaccuracy | 95.37% (autosome) 98.45% (ChrX) | - | - | >99.8% | |||
Paternal allele | Â | Â | Â | Â | |||
Predicted rate | 100% | - | - | 71.60% | 72.84% | 72.94% | |
Prediction accuracy | 98.57% | - | - | 93.79% | 95.84% | 96.56% | |
Accuracy of inferred fetal genotype | Â | Â | Â | Â | Â | Â | |
Autosome | Paternal-only heterozygous | 99.12%, n = 65,409 | 96.8% | 60.3% | - | - | - |
 | Maternal-only heterozygous | 95.84%, n = 66,238 | 99.3%c | 95.7%c | - | - | - |
 | Biparentally heterozygous | 94.90%, n = 41,849 | 98.7%d | 91.3%d | - | - | - |
ChrX | Maternal-only heterozygous | 98.45%, n = 1,932 | - | - | - | - | - |