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Figure 2 | Genome Medicine

Figure 2

From: Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics

Figure 2

Proposed models for the influence of post-translational modifications crosstalk on protein function, showing O -GlcNAc and phosphorylation as an example. Crosstalk may occur by: (a) competitive occupancy: O-GlcNAc occupies a serine, making it unavailable for phosphorylation; (b) steric hindrance from proximal modification that blocks the alternate modifying enzyme from accessing a site located either (i) nearby in the secondary structure or (ii) nearby in the tertiary structure; or (c) modification that regulates the other's enzymatic machinery (O-GlcNAcylation of a kinase prevents auto- or kinase-based activation).

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