Table 2 Post-translational modifications in heart disease
Modification | Stability | Disease state | Proteins investigated | Tissue origin |
|---|---|---|---|---|
Phosphorylation | Transient, reversible | Ischemia/reperfusion | JNK [24] JAK2-STAT3 [25] FAK [26] | Rattus rattus Mus musculus Mus musculus |
N-glycosylation | Stable, reversible | Myocardial infarction Marfan's syndrome Dilated cardiomyopathy Cardiac conductance disorders | Whole proteome [36] Fibrilin-1 [39] Dolichol kinase [40] Sodium channel [37] | Rattus rattus Homo sapiens Homo sapiens Mus musculus |
O-GlcNAcylation | Transient, reversible | Ischemic cell death | Proteins of the hexosamine biosynthesis pathway [53] mitochondrial permeability transition pore [56] | Rattus rattus Rattus rattus |