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Figure 3 | Genome Medicine

Figure 3

From: Isoform level expression profiles provide better cancer signatures than gene level expression profiles

Figure 3

Venn diagram showing the overlapping genes that were significantly upregulated (Up) or downregulated (Dn) either at gene level or isoform level in cancer. If more than one isoform from a single gene were significantly upregulated or downregulated, they were counted only once in the diagram. The differentially expressed genes/transcript variants were obtained by comparing the groups of (A) all non-oncogenic and all oncogenic cell lines, (B) melanocyte and melanoma cell lines and (C) human mammary epithelial cell (HMEC) and human breast adenocarcinoma (MCF7) cell lines. (D) Venn diagram shows the overlap of genes in A, B and C. The overlapping genes that were either upregulated (114 genes) or downregulated (68 genes) both at isoform and gene level were designated as the core isoforms and core genes. The 260 isoforms correspond to 182 unique genes. (E, F) Heat-map diagrams of differential gene expression of (E) core isoforms and (F) core genes.

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