Figure 1

Schematic representation of alterations in protein-protein interactions under pathological conditions. A highly simplified view of how disease-related proteins can drive disease processes by altering individual protein complexes and protein network dynamics. They can replace and co-opt 'steady state' protein complex components or can interfere with normal protein network interactions. By identifying proteins in complex with known disease-related proteins, interacting members of the complex can be then be designated as candidates with a role in pathological progression.