Skip to main content

Table 1 Recent studies utilizing MS for identification of PPIs relevant in human disease

From: Protein-protein interaction networks: probing disease mechanisms using model systems

Model system Disease Approach Reference(s)
Microbes HIV infection AP-MS, co-IP-MS identification of HIV-host PPIs [3638]
  Viral infection AP-MS identification of virus-host PPIs [39]
  Measles AP-MS identification of virus-host PPIs [40]
  Hepatitis C AP-MS identification of virus-host PPIs [41]
  Japanese encephalitis AP-MS identification of virus-host PPIs [42]
  Lyme disease Biochemical fractionation followed by native gel MS identification of protein complexes in outer membrane of Borrelia burgdorferi [45]
  Chlamydia infection Shotgun proteomic identification of Chlamydia trachomatis outer membrane protein complexes [46]
  Bacterial meningitis Two-dimensional native gel MS identification of outer membrane protein complexes in Neisseria meningitides [47]
  MRSA infection AP-MS identification of Staphylococcus aureus protein complexes [48]
  Pneumonia AP-MS of protein complexes in Mycoplasma pneumoniae [49]
Mouse Multiple sclerosis AP-MS identification of LRP-1-interacting proteins [56]
  Huntington's disease AP-MS identification of huntingtin-interacting proteins [57, 58]
  Bovine spongiform encephalopathy AP-MS identification of prion protein interactors [60]
  Schizophrenia AP-MS identification of DLG4 protein interactors [59]
Human Breast cancer AP-MS identification of SCRIB and ER alpha-interacting proteins [71]
  Leber congenital amaurosis AP-MS identification of proteins interacting with mutant lebercilin [72]
  Muscular dystrophy Co-IP MS identification of dystrophyin-interacting proteins [73]
  Lung cancer AP-MS identification of EGFR-associated proteins [75]
  Melanoma AP-MS identification of HIF2-interacting proteins [76]
  1. MRSA, methicillin-resistant Staphylococcus aureus.