Table 1 Recent studies utilizing MS for identification of PPIs relevant in human disease

Microbes

HIV infection

AP-MS, co-IP-MS identification of HIV-host PPIs

[36–38]

Viral infection

AP-MS identification of virus-host PPIs

[39]

Measles

AP-MS identification of virus-host PPIs

[40]

Hepatitis C

AP-MS identification of virus-host PPIs

[41]

Japanese encephalitis

AP-MS identification of virus-host PPIs

[42]

Lyme disease

Biochemical fractionation followed by native gel MS identification of protein complexes in outer membrane of Borrelia burgdorferi

[45]

Chlamydia infection

Shotgun proteomic identification of Chlamydia trachomatis outer membrane protein complexes

[46]

Bacterial meningitis

Two-dimensional native gel MS identification of outer membrane protein complexes in Neisseria meningitides

[47]

MRSA infection

AP-MS identification of Staphylococcus aureus protein complexes

[48]

Pneumonia

AP-MS of protein complexes in Mycoplasma pneumoniae

[49]

Mouse

Multiple sclerosis

AP-MS identification of LRP-1-interacting proteins

[56]

Huntington's disease

AP-MS identification of huntingtin-interacting proteins

[57, 58]

Bovine spongiform encephalopathy

AP-MS identification of prion protein interactors

[60]

Schizophrenia

AP-MS identification of DLG4 protein interactors

[59]

Human

Breast cancer

AP-MS identification of SCRIB and ER alpha-interacting proteins

[71]

Leber congenital amaurosis

AP-MS identification of proteins interacting with mutant lebercilin

[72]

Muscular dystrophy

Co-IP MS identification of dystrophyin-interacting proteins

[73]

Lung cancer

AP-MS identification of EGFR-associated proteins

[75]

Melanoma

AP-MS identification of HIF2-interacting proteins

[76]