Table 1 Recent studies utilizing MS for identification of PPIs relevant in human disease
From: Protein-protein interaction networks: probing disease mechanisms using model systems
| Model system | Disease | Approach | Reference(s) |
|---|---|---|---|
| Microbes | HIV infection | AP-MS, co-IP-MS identification of HIV-host PPIs | [36–38] |
| Viral infection | AP-MS identification of virus-host PPIs | [39] | |
| Measles | AP-MS identification of virus-host PPIs | [40] | |
| Hepatitis C | AP-MS identification of virus-host PPIs | [41] | |
| Japanese encephalitis | AP-MS identification of virus-host PPIs | [42] | |
| Lyme disease | Biochemical fractionation followed by native gel MS identification of protein complexes in outer membrane of Borrelia burgdorferi | [45] | |
| Chlamydia infection | Shotgun proteomic identification of Chlamydia trachomatis outer membrane protein complexes | [46] | |
| Bacterial meningitis | Two-dimensional native gel MS identification of outer membrane protein complexes in Neisseria meningitides | [47] | |
| MRSA infection | AP-MS identification of Staphylococcus aureus protein complexes | [48] | |
| Pneumonia | AP-MS of protein complexes in Mycoplasma pneumoniae | [49] | |
| Mouse | Multiple sclerosis | AP-MS identification of LRP-1-interacting proteins | [56] |
| Huntington's disease | AP-MS identification of huntingtin-interacting proteins | [57, 58] | |
| Bovine spongiform encephalopathy | AP-MS identification of prion protein interactors | [60] | |
| Schizophrenia | AP-MS identification of DLG4 protein interactors | [59] | |
| Human | Breast cancer | AP-MS identification of SCRIB and ER alpha-interacting proteins | [71] |
| Leber congenital amaurosis | AP-MS identification of proteins interacting with mutant lebercilin | [72] | |
| Muscular dystrophy | Co-IP MS identification of dystrophyin-interacting proteins | [73] | |
| Lung cancer | AP-MS identification of EGFR-associated proteins | [75] | |
| Melanoma | AP-MS identification of HIF2-interacting proteins | [76] |